有害重金属离子污染一直是人体健康和环境安全所面临的重大问题之一。发展快速、灵敏、高选择性地检测有害重金属离子的方法已成为控制和处理重金属离子污染的关键环节。基于我们已有的研究基础，该申请项目拟根据有害重金属离子与核酸生物分子的特异性相互作用，通过生物条形码和纳米复合材料为标记物的多重信号放大策略，结合电化学检测技术快速、灵敏、廉价、便携的优点，旨在建立低浓度、高毒性、难降解有害重金属离子（包括：Hg2+、Pb2+、Ag+、Cu2+、Zn2+等）的高灵敏、多组分同时仿生电化学传感方法，为重金属污染的监管、监测和突发性污染事故的预警与应急提供有价值的理论依据和方法指导。

Toxic heavy metal ion contamination is one of the most serious concerns to human health and environment. The development of rapid, sensitive and selective methods for the detection of heavy metal ions plays crucial roles in the monitoring of contaminations by these ions. On the basis of the specific interactions between heavy metal ions and DNA and signal amplifications by biobarcode and nanocomposite material labels, the goal of this proposal is to establish highly sensitive electrochemical biosensors for the detection of low concentration, highly toxic and non-degradable heavy metal ions (e.g., Hg2+, Pb2+, Ag+, Cu2+, Zn2+). The proposed study is expected to provide valuable theoretical base for the development of biosensor technology for heavy metal ion monitoring.