2型糖尿病是威胁人类健康的主要疾病，其发病过程中胰岛细胞量逐渐丢失，最终导致胰岛素分泌不足，出现高血糖。如何保护功能性胰岛细胞量一直是糖尿病治疗的重点。近年研究发现胰岛除分泌经典激素外还分泌生存因子，其在局部对细胞的发育、生存和保护起着重要作用。我们近期的研究提示：在代谢紊乱环境下，生存因子Netrin-1能促进胰岛β细胞增殖，增加局部毛细血管新生，但其机制仍不清楚。我们希望在Netrin-1高表达或表达抑制情况下从体内、体外两方面阐明Netrin-1与胰岛细胞量及胰岛内毛细血管增生和功能的关系；同时从经典的信号通路入手，探讨其可能的作用机制。这项研究将为如何保存胰岛细胞量，恢复胰岛细胞功能提供新的理论和实验依据，为2型糖尿病治疗提供新的思路和作用靶点。

Type 2 diabetes is a major disease to threat human health. Since diabetes results from a deficiency of in functional beta cell mass, finally patients with type 2 diabetes have high blood glucose due to inadequate insulin secretion. How to protect islets and increase functional beta cell mass is a major research goal in the diabetes treatment studies. Recently, some studies show that islet cells can also produce and secret some survival factors besides the classical hormones including insulin, glucagon and somatostatin. These survival factors play major role in the process of cell survival and growth in the local areas. Our research shows that survival factor netrin-1 promotes the proliferation of islet beta cells, increases angiogenesis of local vessel in the metabolic disorder environment. The study groups are very interested in this phenomenon. So in this research, we still focus on the survival factor netrin-1. The role of netrin-1 in beta cell function, apoptosis and proliferation are examined. The effect of netrin-1 on the capillary cell is also studied. In the diabetes model, the proliferation and survival of islets and the capillary surrounding the islets are observed after treatment. At the same time, the mechanism is explored in the classical signal pathways. These studies are important steps towards developing novel therapies too improve beta cell survival.