心血管疾病已经成为严重危害人类生命健康的最常见疾病之一。利用核医学分子影像方法早期、快速准确地诊断疾病，在心血管病的预防和治疗中占有重要地位。核影像探针，特别是心肌脂肪酸代谢显像剂，能正确反应心肌中脂肪酸的代谢情况，为心肌的功能评估提供了一种无创、灵敏、准确的方法。但在国内分子影像设备迅速发展的同时，作为分子影像重要组成之一的显像剂的研制一直处于滞后的状态。本项目旨在对新型99mTc标记的系列心肌脂肪酸显像剂的设计、合成与性能进行研究，研制出可用于分子影像的理想心肌脂肪酸代谢显像剂。通过生物分布、microSPECT显像等对所得的放射性分子探针进行评价，了解其在生物体内的分布和代谢情况。并通过心肌缺血模型的显像筛选并评价该类新型心肌脂肪酸代谢显像剂在心肌显像和病理研究方面的优势及可行性。本研究可为心肌显像剂与心肌功能评价手段的发展提供科学依据，对于心脏疾病的早期诊断和早期治疗具有积极的意义

Cardiovascular disease is one of the most common diseases and is a serious health problem worldwide. Early , quickly and accurately diagnosis plays an important role in the prevention and treatment of cardiovascular diseases in clinical trials. Nuclear medicine imaging probes, especially fatty acid metabolic imaging agent, can evaluate myocardial fatty acid metabolism, and provides a noninvasive, sensitive and accurate method to assess myocardial function. However, the progress of fatty acid probes was relatively slow, while molecular imaging equipment development was rapid. This project aims at design, synthesis and evaluation of novel 99mTc-labeled long chain fatty acid derivative for myocardial metabolic imaging. The radiolabelled molecular probes were studied with biodistribution and microSPECT imaging to evaluate in vivo distribution and metabolism. Imaging study with myocardial ischemia model also used to evaluate the advantages and potential application of the novel fatty acid imaging agents for myocardial perfusion imaging in the future. This project can provide scientific data for development of myocardial metabolic imaging probes and method for evaluation of myocardial function. The research has positive significance for early diagnosis of cardiovascular disease.