记忆功能受损为核心临床特征的遗忘型轻度认知障碍（aMCI）及情绪障碍为主要表现的老年期抑郁（LLD）患者均是阿尔茨海默病（AD）的高风险人群。基于Aβ-淀粉样蛋白代谢通路相关基因的随访遗传影像学策略探寻AD风险人群的神经环路动态演变模式在国内外尚处于空白。研究团队将在中国汉族人群中同期选择aMCI和LLD患者及其匹配健康对照组人群进行三年随访研究，结合多模态fMRI技术和多维度认知神经心理量表测试，从Aβ-淀粉样蛋白代谢通路水平上随访探讨不同AD风险人群的神经影像特征动态演变的内在关联及相互差异，评估该通路基因多态性的集聚效应对AD风险人群的诊断价值，为预防或延缓aMCI和LLD患者向AD的转化以及AD 的早期诊断与治疗提供理论依据。

Impaired memory function for the core clinical features of amnestic mild cognitive impairment (aMCI) and mood disorders as the main manifestation of late-life depression (LLD), who are associated with high risk of Alzheimer's disease (AD). Little is known about the dynamic neural networks model based on genetic imaging strategy of β-amyloid (Aβ) protein metabolic pathway in the AD risk populations. In the present study, we recruited the aMCI patients, LLD patients and well matched controls with age, gender and education. Full-scale neuropsychological tests were used to evaluate the cognitive function in these subjects, and three-year longitudinal multi-modality fMRI was then performed. The present study yielded four main research directions: (1) To reveal the relationship between genetic factors and cognitive key brain regions and whole brain network. (2) To explore the intrinsic association and differences of AD risk populations in the neuroimaging characteristics of dynamic neural networks model based on Aβ protein metabolic pathway. (3) To assess the diagnostic value of the AD-risk populations using the clustering effect of the gene polymorphisms of Aβ protein metabolic pathway. (4) To provide a theoretical basis for preventing or delaying the the progression of aMCI and LLD patients and for the early diagnosis and treatment of AD.