四环素类药物(TCs)是目前我国养蜂生产中最常用的抗生素之一。 本项目以蜜蜂工蜂和蜂蜜为研究对象，建立各介质中TCs及其代谢物的快速、准确分析方法；开展饲喂后TCs在工蜂体中的代谢动力学研究，开展短期贮存和加工过程中蜂蜜TCs的降解消除规律研究。项目将为蜂产品加工、贮存条件的合理配置提供理论依据，也为下一步开展TCs在蜂巢系统和蜂产品中的蓄积、分布和代谢规律研究打下基础。

Tetracyclines(TCs) are the major drugs used in beekeeping. In this study, we intend to (1) develop quick and accurate methods to analyze the TCs and their metabolites in worker-bees and honey;(2) evaluate the pharmacokinetics of TCs in woeker-bees; (3) research how the residues in honey eliminate in the short-period storage and manufacturing processes. The results will provide theoretical basis for reasonable allocation of honey storage and manufacturing processes, and lay a foundation for further research on distribution, accumulation,translocation and metabolism pattern in bee-hive system and beeproducts.