肌细胞膜Caveolin-3(CAV3)蛋白能调节胰岛素受体信号途径，影响细胞的糖代谢。国外人种已报道七种与CAV3基因变异相关的严重疾病， CAV3变异通过影响肌细胞的胰岛素信号途径、延缓钾离子和钙离子通道开放及改变肌细胞结构，导致相关肌病的肌无力、肌肥大表现以及长QT综合征、窦性停搏猝死等；同时也使全身肌肉对葡萄糖的摄取利用减少，参与2型糖尿病人的高血糖及心肌病的发生。我们把CAV3基因变异导致的多种疾病统称为CAV3肌病。本研究通过临床筛查，可以对我国该类疾病进行正确了解，避免错误的诊治；局部注射转基因处理，观察是否扭转糖尿病心肌病小鼠的骨骼肌和心肌的结构紊乱和收缩功能，为今后临床诊治该类疾病进行前期尝试。

Membrane Caveolin-3 (CAV3) protein of muscl cell can regulate insulin receptor signaling pathways and glucose metabolism in cells. Foreign people have been reported that CAV3 gene mutations are related to seven serious diseases, through affecting insulin signaling pathway of muscle cells, delaying the potassium and calcium channels and change the cell structure, causing myopathy weakness, muscle hypertrophy and long QT syndrome, sinus arrest and sudden death; also reduced glucose uptake in the muscle of whole body , and the occurrence and development of hyperglycemia with myocardiosis in patients with type 2 diabetes. CAV3 gene mutation causes many diseases called CAV3 myopathy in total. through screening the clinical samples, this study improves the understanding of this kinds of diseases in China, to avoid the wrong diagnosis and treatment. And to observe whether the skeletal muscle and cardiac muscle of rats with diabetic cardiomyopathy can be reversed in the structural disorder and contractile function.