真菌感染危害极大，但抗真菌药物相对较少，且抗真菌免疫信号通路的研究尚不充分。深入挖掘抗真菌免疫信号通路的调节机制，对于抗真菌药物的研发十分重要。我们之前通过一系列相互关联的工作，系统地阐释了TAGAP、EPHB2分子在抗真菌信号通路中发挥的作用（Nature Communications，2020年；Journal of Immunology-Cutting Edge，2021年）。在之前研究的基础上，我们通过研究进一步发现TAGAP的相互作用蛋白DOCK2在抗真菌信号通路中发挥了重要的作用。通过初步的分子机制研究，我们发现DOCK2对于真菌诱导的RAC1激活以及活性氧的产生至关重要。下一步，我们将在分子、细胞以及动物整体水平深入研究DOCK2参与抗真菌免疫的机制。我们希望通过该研究，不仅能够进一步了解机体抗真菌信号转导的调控机制，并能为抗真菌感染以及药物筛选提供线索和靶点。

Fungal infection causes great harm to human beings, but there are few antifungal drugs, and the research on antifungal immune signaling pathway is not sufficient. Therefore, it is very important to study the regulation mechanism of antifungal immune signaling pathway, which is useful for the development of antifungal drugs. We have systematically explained the roles and mechanisms of TAGAP and EPHB2 in the antifungal signaling pathway through a series of related studies (Nature Communications, 2020; Journal of Immunology-Cutting Edge, 2021). Based on the previous studies, we further found that DOCK2, which is a TAGAP-interacting protein, plays an important role in the activation of antifungal signaling pathway. Through the preliminary mechanistic study, we found that DOCK2 is crucial for fungus-induced RAC1 activation and reactive oxygen species production. In the next step, we will further investigate the mechanistic role of DOCK2 in antifungal immunity at the molecular, cellular and animal levels. Through this study, we hope that we can not only further understand the mechanism of anti-fungal signal transduction, but also provide clues and therapeutic targets for antifungal therapy and drug screening.