临床观察PD双侧STN-DBS术后会发生认知不良事件。目前DBS对PD认知功能影响的确切机制尚不明确，且缺少预测术后认知功能的神经影像学标记物。我们前期研究了PD术后脑白质与运动功能的相关性，发现运动症状改善时，运动和非运动脑区间的白质连通性均有显著增强；预实验结果提示DBS可能会影响术后认知网络“小世界”拓扑属性。由此提出假设：非运动脑区白质连通性的增加与术后认知下降相关，并且可能是通过影响认知网络结构连通性的拓扑属性从而影响认知功能。本课题将利用DBSproc对STN激活组织范围VTA有限元模拟，并与认知功能网络进行DTI研究，分析术后FA、MD、RD、fNT等白质纤维特征性参数变化；利用图论对认知功能网络白质连接模块分类、中心度等拓扑性分析；初步建立数学模型探讨结构连通性与术后认知变化的关系。本课题旨在阐明DBS术后与认知功能相关的脑结构连通性机制，为DBS临床安全应用提供循证依据。

Clinical studies oberseve bilateral STN-DBS treatment can cause adverse cognitive events in PD patients. At present, the prompt mechanism of DBS's influence on cognitive function is not clear, and there is lacking of neuroimaging biomarkers that can be used to predict cognitive function. We found in our previous study that there was a correlation between the white matter connectivity with the improvement of motor symptoms, either the connectivity of the white matter between the motor or non-motor brain regions were significantly enhanced in PD patients. Our pre-experimental results suggest that DBS may affect the “small world”topological attributions of the cognitive functional network as well. Thus, we hypothesize that increased white matter connectivity in non-motor brain regions is associated with triggering adverse cognitive events, and may affect cognitive function by affected white matter structure connectivity of the topological attributions of the congnitive functional network. Thus, in current study, DBSproc will be used to simulate the volume of tissue activated in STN based on finite element model, and conducts DTI research with cognitive function network, analyzes and traces the changes of white matter fiber characteristic parameters such as FA, MD, RD, fNT. White matter connection module classification and center degree of distortion analysis using graph theory will be used to analyze the topological attributions of cognitive function network. Initially establish a mathematical model to explore the relationship between structural connectivity and the relationship with post-DBS cognitive changes. The study aims to clear that the brain structure connectivity mechanism related to cognitive function after DBS operation provides evidence-based evidence for the clinical safety of DBS.