灭酸类NSAIDs在环境水中残留普遍，会在生物体内富集并通过食物链的放大作用对人类健康产生危害。本项目前期发现灭酸类NSAIDs在饮用水氯消毒过程中降解迅速，且产生了毒性更强的转化产物（TPs）。但是在氯消毒过程中影响该类药物降解速率的因素、不同TPs毒性表现及TPs结构和毒性之间的关系仍不明确。据此，本项目拟选取五种灭酸类NSAIDs，系统研究其氯降解过程，考察氯浓度、溶液pH、分析物初始浓度及天然水体中各种共存物质对氯降解速率的影响；采用多种分析技术手段鉴定TPs的结构，阐明灭酸类NSAIDs的氯降解机理，并测定各TP的相对含量；应用三种毒性测试方法评价TPs的遗传毒性、致畸性和肝毒性，探讨TPs结构与毒性效应之间的关系。本项目的成功实施将为我国开展饮用水氯消毒过程中该类药物及其TPs残留的环境风险评估提供科学依据，为TPs去除方法的制定提供研究思路，对水质安全评价具有重要意义。

It has been reported that fenamate NSAIDs are frequently detected in environmental water. They could be accumulated in organics and pose harm to humans by the enlargement effect of the food chain. In early stage of this project, we found that fenamate NSAIDs degraded rapidly and produced transformation products (TPs) with enhanced toxicity during drinking water chlorination. However, it is still unclear that the factors affecting the degradation rates during chlorination process, the toxicity of different TPs, as well as the relationship between the structures of TPs and toxicity. On the basis of these facts, this project will be carried out three parts focusing on five fenamate NSAIDs: 1) researching the effects of several factors on the degradation rates, including the chlorine concentration, pH of the solution, the initial concentration of analytes and various coexisting substances in natural water; 2) identifying the structures of TPs via various analytical techniques, thus clarifying the mechanism of chlorine degradation of fenamate NSAIDs; determining the relative content of each TP as well; 3) evaluating the genotoxicity, teratogenicity and liver toxicity of TPs through three toxicity test methods, and exploring the relationship between the toxic effects and the structures of TPs. The successful implementation of this project will provide scientific basis for the environmental risk assessment of residual fenamate NSAIDs and their TPs during drinking water chlorination in China. Also, it will provide research ideas for the methods formulation of the removal of TPs. It is of great significance to evaluate the water safety.