COPD是一种以持续性气流受阻为特征的疾病，病情呈进行性进展，其发病率、住院率、死亡率高，给社会和经济造成沉重的负担，目前COPD的发病机制尚未完全明了，而气道粘液高分泌存在于COPD发生、发展的各个阶段，已成为影响COPD病情及预后的独立危险因素。COPD气道粘液高分泌发病机制复杂，IL-1β/COX-2信号通路是调节气道粘液高分泌的一条重要的细胞转录途径，能减少气道阻塞，改善肺功能及运动耐力，减少预后急性加重频率，目前西药抑制COPD气道粘液高分泌的药物有限而疗效不理想。苗药吉祥草具有清肺热、止咳化痰功效，大量临床证实，吉祥草能改善COPD气道粘液高分泌患者高分泌状态，减少痰液量，使痰液由稠变稀，为进一步明确其作用机制本课题拟通过基于IL-1β/COX-2信号通路探讨苗药吉祥草抑制COPD气道粘液高分泌的分子机制研究，明确其作用机制，为苗药治疗COPD以及进一步开发利用苗药打下实验基础

Hronic obstructive pulmonary disease is a disease characterized by continuous flow limited.With the worsening of human living environment, the incidence of COPD is heighten, so it is urgent for patients and medical workers to looking for a safe and effective treatment.Studies have shown that high airway mucus secretion is one of the important pathophysiological features of COPD, which is exists in the occurrence,development stages. COPD airway mucus secretion has become a high impact condition and prognosis independent risk factor for COPD.At the present,the molecular mechanism of high COPD airway mucus secretion is not fully clear.Among them,the study based on IL - 1 beta/cox-2 signaling pathways of high airway mucus was seldom researched. At the present.Western medicine treatment of COPD airway mucus secretion is less and curative effect is poor.A large number of clinical studies have confirmed that Chinese medicine especially the folk medicine for the treatment of COPD airway mucus secretion of high effect is remarkable.In addition the miao medicine of Jixiangcao has the effect of relieving cough ,reducing sputum  and clearing away lung heat, reducing sputum, Studies have confirmed that Jixiangcao have inhibitory effect on high COPD airway mucosa secretion. This topic is based on IL - 1 beta/cox-2 signalingpathway to explore Jixiangcao molecular mechanism of high inhibition of COPD airway mucus secretion.That led to researching and developing of new drugs in the folk medicine which is treat for COPD .