POCD依然是目前围术期医学的重要研究课题之一，但仍未解决老年患者POCD易感性的原因。我们研究发现EAAT3功能与POCD密切相关：其一，海马神经元EAAT3功能与学习记忆密切相关；其二，手术创伤等因素可致海马EAAT3表达下调，而抗氧化剂依达拉奉可以改善EAAT3的表达，其变化规律与实验鼠发生POCD的时相一致。进一步的临床研究发现不同年龄人群表达EAAT3的转录基因SLC1A1/slc1a1的外显子基因突变存在明显差异。综上所述，我们认为EAAT3转录基因突变导致海马神经EAAT3功能低下可能是老年患者POCD易感性的重要原因。因此，本研究拟结合动物实验和临床研究对EAAT3功能在老年患者POCD易感性增强中的重要作用进行深入研究；同时结合特定基因测序及相关生化指标检测，研究探索预测老年患者发生POCD方案的可行性，研究结果旨在为老年患者POCD防治研究提供依据与支持。

Postoperative cognitive dysfunction (POCD) is still one of the most important research subjects in perioperative medicine, but it has not yet solved the cause of POCD susceptibility in elderly patients. Our previous study found that EAAT3 function is closely related with POCD: first, hippocampal neurons EAAT3 function related to learning and memory; second, surgical trauma and other factors can decrease hippocampal EAAT3 expression, while antioxidant edaravone can improve hippocampal EAAT3 expression, POCD with the changes of experimental rats is consistent. Further clinical studies showed that there were significant differences in exon of SLC1A1/slc1a1 gene in different age groups that transcribe EAAT3. To sum up, we suppose that the EAAT3 gene mutation leads to the dysfunction of EAAT3 in the hippocampus, which may be an important reason of POCD susceptibility in elderly patients. Therefore, this study will be combined with animal experiments and clinical studies to investigate the role of EAAT3 in regulating the susceptibility of POCD in elderly patients; At the same time, we will combine with specific gene sequencing and related biochemical indicators detecting to research the early warning, prevention and even the treatment of the elderly patients who prone to POCD. In one word, the aim of this study is to explore the influencing factors and early warning index of POCD susceptibility in elderly patients.