基于四苯并环辛四烯骨架设计合成手性Bronsted酸碱催化剂及其在不对称催化中的应用研究

四苯并环辛四烯分子具有刚性强，构型稳定，较小二面角的特点，通过对手性四苯并环辛四烯骨架进行合成，修饰，安装胍基，磷酸基，NHTf和磷腈等功能基团，设计和合成新颖的Br?nsted酸碱催化剂，并应用到不对称催化反应中。据此开发的催化剂有望在不对称合成中取得优秀的手性诱导效果。本计划将着重考察催化剂在反应体系中的集结状态，研究其催化机理，并希望催化不对称反应，合成非天然氨基酸及其衍生的肽类化合物。四苯并环辛四烯催化剂的合成和应用研究将加深同行对该骨架的理解，为发展新的手性催化剂打下基础。

Tetraphenylene is a structurally rigid and thermally stable molecule possessing a narrow dihedral angle.In view of these characteristics,some novel Br?nsted acid or base catalysts synthesized by direct installation of guanidine, phosphate, NHTf or phosphazene functional groups on the tetraphenylenes and their evaluation in asymmetric reactions were proposed. The catalysts are expected to give excellent results in asymmetric catalysis. In this research project, studies were also focused on clarification of its catalytic mechanism concerning with the catalyst assembly and their applications in preparation of non-natural amino acids as drug leading compounds.These catalysts with tetraphenylene backbone, if possible, enable to attract considerable attention on tetraphenylenes and inspire the researchers to explore new skeleton derivatived chiral catalysts in the fields of asymmetric synthesis.