手性是自然界的普遍现象，在生命科学、制药以及材料科学中起着重要的作用。基于Trӧger碱特殊的V型结构以及手性，本项目拟开展以下研究工作：1）设计合成系列含Trӧger碱骨架的手性大环主体； 2）以双Trӧger碱分子为出发点，研究其方型空腔以及腔内/腔外的手征性；3）构筑手性网络聚集体，特别是手性3D框架结构；4）研究基于Trӧger碱大环构筑的超分子组装体在手性识别与不对称催化中的应用。本项目研究将为设计合成具有特殊形状与性质的主体以及基于该主体构建特殊的超分子手性组装体系提供更广阔的思路。

Chirality is the universal phenomenon in nature and plays an important role in life science, pharmacy and material science. Based on the special V-shape and the inherent chirality of Trӧger base, the research mainly included three parts: 1) Firstly, design and synthesis of chiral macrocycles which contain two or more Trӧger base motifs; 2) Secondly, taking bis-Trӧger base motifs as examples, and studying the chirality in/off the square cavity; 3) Thirdly, constructing chiral network aggregates, especially 3D frameworks; 4) Fourthly, utilizing these supramolecular chiral systems in chiral recognitions and asymmetric reactions. The research of this project will provide a broader idea for the design and synthesis of hosts with special shape and character, and for the construction of the corresponding special supramolecular chiral assembly systems.