活性天然产物从始至终对于人类新药研发具有战略意义。许多天然产物具有非常好的生物活性，但是通常这些天然产物在动植物或微生物中含量极微，分离纯化困难，使其难以得到足够量的化合物进行进一步的生物学研究。申请人的研究重点集中于探索该分子内Pauson-Khand反应的底物适用性、反应的简洁高效性，实现含 [6, 5]并环骨架结构的活性天然产物全合成。4-desmethyl-rippertene家族天然产物分子含有核心的[6, 5]并环骨架结构，而暂时的生物活性研究表明其最初是作为信息素被发现的，能有效帮助生物进行自我保护，而对于其进一步深入的生物活性研究和生物学作用机制尚不清楚。旨在通过分子内Pauson-Khand反应作为关键反应，通过简洁高效的合成策略完成4-desmethyl-rippertene及其家族天然产物分子的克级制备，为后续生物活性研究和生物学作用机制研究提供化学基础。

The biological activity of natural products has been playing a strategic significance in the development of medicine. However, the isolation of natural products with good biological activity from plants and microbes are rare. As well as the difficulties in the separation and purification result that it's difficult to get a sufficient amount of these compounds for the further biological research. This application focus on the exploration and the applicability of substrates scope in the intramolecular Pauson-Khand reaction, and realize the concise total synthesis of the active natural products containing [6, 5]-bicyclic framework. The family members of 4-desmethyl-rippertene contain the core [6, 5]-bicyclic ring skeleton, and the biological active studies showed that it's pheromone, which can be used for the self-preservation . Meanwhile the further study of biological activity and biological mechanism is still unknown. The gram scalabe preparation of 4-desmethyl-rippertene and its family members via the intramolecular Pauson-Khand reaction as key step could provide the foundation for the further study of the biological activity and biological mechanism.