乳腺癌是女性最常见的恶性肿瘤之一,而转移是乳腺癌患者死亡的主要原因。肿瘤转移是一个复杂的、多因素调控的动态过程。睾丸特异性蛋白50（testes specific protein 50, TSP50）是近年来新发现的一个原癌基因，在正常情况下，其表达局限在男性睾丸中，而在其它组织不表达或低表达，但是该基因却异常高表达在乳腺癌组织中。我们以往的研究结果显示，TSP50可通过激活NF-kB信号促进细胞的体外增殖能力及体内成瘤能力。进一步的研究结果显示，TSP50亦可增强细胞的迁移及侵袭能力，但NF-κB信号在TSP50诱导的乳腺癌细胞侵袭及转移中是否发挥至关重要的作用及其具体机制尚不十分清楚。因此本研究拟对NF-κB信号通路在TSP50诱导的乳腺癌细胞侵袭及转移中的作用及机制进行研究，以期阐明TSP50促进乳腺癌转移的机制，并进一步为乳腺癌的治疗提供新的途径。

Breast cancer is the most common cancer in women, and its metastasis is the leading cause of death in breast cancer patients.Tumor metastasis is a complex and many factors controled dynamic process. Testes specific protein 50 is a novelly identified protooncogene recent years. It is highly expressed in human testes, and not or low expressed in other normal tissues, but it is expressed abnormally at high levels in breast cancer tissues. Our previous results revealed that TSP50 can promote cell proliferation and tumor formation through activation of the NF-kappa beta (NF-κB) signaling pathway. Further results indicated that TSP50 also enhance cell motility and invation, but if the NF-kB signal also involved in TSP50 induced breast cancer invation and metastasis, and what is the mechanism are still unclear. In the present project, we will investigate the function and mechanisms of NF-kB signal in TSP50 induced breast cancer cell invation and metastasis, thereby clarify the mechanisms of TSP50 induced breast cancer metastasis, and further provide a noval approach for breast cancer therapy.