线粒体是真核生物细胞最重要的细胞器，与肿瘤发生关系密切。线粒体动力学平衡的改变能够通过线粒体自噬与凋亡途径决定肿瘤细胞的命运，因此线粒体动力学调控是肿瘤线粒体调控的关键环节，在课题负责人的博士课题中首次明确了线粒体动力学失衡在急性白血病尤其是复发难治急性白血病发病中的重要作用。本研究是在博士课题前期研究基础上，以较为成熟的NOD/SCID急性白血病模型为研究对象，以临床上治疗白血病疗效显著、单味中药或有效成分抗白血病效应明确的升麻鳖甲汤进行干预，并依据《金匮要略》中“阴阳毒病”证治规律对其进行拆方研究，探讨该方对于线粒体调控的关键环节-线粒体动力学的干预作用，以进一步阐明中医传统理论对急性白血病诊治的指导意义，为中医药传统理论结合细胞和分子生物学诊治急性白血病提供新的思路。

Mitochondria are the most important organelles in eukaryotic cells, and are closely related to tumorigenesis。Changes in the balance of mitochondrial dynamics can determine the fate of tumor cells through the mitochondrial autophagy and apoptosis pathways, so mitochondrial dynamics regulation is a key link in the regulation of tumor mitochondria.In my doctoral project, the important role of mitochondrial dynamic imbalance in the pathogenesis of acute leukemia, especially the relapsing refractory leukemia, was clarified for the first time.On the basis of the previous research of my doctor's project, this study will take relatively mature NOD/SCID animal model of leukemia as the research object, and used shengmabiejia decoction with remarkable clinical efficacy to intervene in the treatment of leukemia，and study on the effect of mitochondrial dynamics under the intervention of shengmabiejia decoction based on the syndrome and treatment rules of "yin-yang toxicosis" in synopsis of the golden chamber,we explore to illuminate the guiding significance of traditional Chinese medicine theory to the diagnosis and treatment of malignant blood system diseases,provide new ideas for the Chinese medicine diagnosis and treatment in acute leukemia under the guidance of the traditional theory, modern cell and molecular biology.