基于微纳米技术的微纳流体系统的发展，使其在机械、生物、化学、医学以及生物医学等领域取得了引人瞩目的业绩。目前微纳米尺度下的流体阻力的控制已成为制约微纳流体系统发展的关键因素之一，对流体阻力的形成机理和影响因素的研究具有重要的理论意义和实用价值。本课题首先利用理论分析和实验相结合的方法研究固液界面上纳米气泡影响边界滑移的机理，得到纳米气泡对液体流动阻力的影响规律；然后以固液气三态耦合理论为基础，分析表面电荷、电粘度效应、边界滑移和纳米气泡之间耦合作用机理，建立一、二维微纳通道内的流速场数学模型，得到微纳尺度下固液界面流体阻力多因素耦合影响机理及规律。利用改造后具有外加电场功能的AFM测量固液界面纳米气泡特征参数、表面电荷密度、边界滑移长度，同时利用微流量计测量微纳管道流量流速，验证理论分析结果的正确性。最后探索一种基于改变表面电荷密度实现控制微纳流体系统内流动阻力的方法。

Micro/Nanofluidic systems, which are developed based on the micro/ nano technology, obtained remarkable achievements in mechanical, biological, chemical and biomedical applications. The control of the drag of fluid flow in micro/ nano scale is one of the key factors for the development of Micro/nanofluidic systems. The study of the formation mechanism and influence factors of the drag of fluid flow has important theoretical and practical value. This research firstly studies the effect of nanobubbles on the boundary slip at the interface of solid and liquid based on theoretical analysis and experimental methods, and obtains the effect of nanobubbles on the drag of liquid flow. Secondly, the co-influence of surface charge, electroviscosity, boundary slip and nanobubbles are investigated based on the solid, liquid, gas coupling theory, and one-dimensional and two-dimensional mathematical models of the velocity field within the micro/ nano scale channels are established to obtain the co-effects on the drag of fluid flow in micro/ nano scale. Then the characteristic parameters of nanobubbles, surface charge density and slip length are measured using an modified AFM which can applies electric filed to the experimental system, at the meantime, the flow rate of micro/nano pipeline flow is measured by using micro-flowmeter to verify the theoretical analysis. Finally a method which can control the drag of fluid flow in micro/nanofluidic system by changing the surface charge density is explored.