网膜是卵巢癌转移的主要靶器官之一。发生网膜转移的卵巢癌患者预后极差，而目前其机制尚不清楚。我们前期研究发现在尚无网膜转移的卵巢癌病人网膜组织中已可见活化的成纤维细胞，这提示在卵巢癌细胞到达网膜前就开始了对网膜微环境的 "远程教育"，形成转移前微环境，从而促进网膜转移的发生。推测其机制可能是由肿瘤细胞产生的一系列因子(TGF-β，IL-1β和IL-8)等，对网膜组织中的成纤维细胞、巨噬细胞和内皮细胞进行综合改造，从而形成活化的微环境，通过影响肿瘤细胞的粘附、侵袭、增殖和凋亡促进网膜转移的发生。本课题旨在以网膜组织中的各类主要细胞为研究对象，在前期研究的基础上进一步深入探讨卵巢癌网膜转移前微环境的形成及其机制，并阐明它促进卵巢癌发生网膜转移的主要通路，形成完整的卵巢癌对网膜微环境 "远程教育"理论，从网膜微环境的角度阐明卵巢癌网膜转移机制，并为抑制卵巢癌的转移寻找新的靶点。

Omentum is one of the most common target organs of ovarian cancer metastasis. Omentum metastasis is associated with poor outcomes of patients with ovarian cancer. However, the mechanisms underlying of omentum metastasis in ovarian cancer are still not clear. Our previous studies have proved evidence that the fibroblasts can be activated by ovarian cancer cells in omentum without metastase, suggesting that tumor cells change omentum microenvironments via a 'distance education' model, establishing pro-metastatic niche in omentum which facilitate the targeting metastasis of tumor cells. We speculate that the ovarian cancer cells stimulate the fibroblasts, endothelia and macrophages in omentum through secreting several factors, such as TGF-β，IL-1βand IL-8, before they arrive, and the activated omentum microenvironments provide convenience for tumor metastasis via affecting the abilities of adhesion, invasion, proliferation and apoptosis of tumor cells. The aim of our present project is to investigate how ovarian cancer cells make the pre-metastatic niche in omentum via a 'distance education' model and how these changes in omentum facilitate tumor metastasis. Our study will form a radical new theory about mechanisms of omentum metastasis in ovarian cancer and explore promising drug targets of inhibition of ovarian cancer metastasis.