在复制时相性偏头痛大鼠模型的基础上，对偏头痛营卫失和病机理论进行基础研究。选择调和营卫的经典药对桂枝-白芍，在文献整理和临床应用的基础上确定三个剂量并考虑单独使用桂枝或白芍的情况，按照2因素4水平的正交实验设计进行实验研究，确定桂枝/白芍的最佳剂量和配比，并在此基础上，通过大鼠行为学观察、软脑膜血管管径变化、脑组织血灌注量、血神经肽（ET-1、NO）含量测定、脑干神经递质含量检测、c-fos基因和NF-κB基因表达的测定，科学研究调和营卫法对偏头痛模型大鼠的脑血流和血管内皮功能的调节机制，探讨调营、调卫和调营卫治疗偏头痛缓解期的血流和血管内皮功能机制，并从调节神经递质、条件炎症级联反应等不同角度，在器官、细胞、分子和基因的不同层次，阐释调和营卫法治疗偏头痛缓解期的理论体系。

On the basis of the phase-related migraine rat model, we select the cassia twig- white peony root which is the classic drugs pair used to harmonize Ying and Wei to treat migrane remission stage.Through the two factors and four levels or thogonal experiment design, we determine the optimal dose and ratio. The rat behavior,the change of the pial vessel diameter,cerebral blood flow, the content of ET-1、NO in blood and brain stem neurotransmitter,c-fos gene and NF - B expression are all recorded. Researching regulatory mechanism of migraine rat model of cerebral blood flow and endothelial function scientificaly,and exploring the mechanism of harmonizing Ying and harmonizing Wei and harmonizing Ying and Wei to treat migraine remission stage of blood flow and vascular endothelial function ,and from different angles of regulation of neurotransmitter and conditions of the inflammatory cascade and at different levels of the organs, cells, molecules and genes to explain the theoretical system of harmonizing Ying and Wei to treat migraine remission stage.