亚胺的催化不对称芳基加成反应是对映选择性合成重要手性alfa-芳基胺化合物的有效途径。鉴于之前的方法大都依赖于使用各种芳基金属试剂如芳基硼酸，原子经济性欠佳，本项目拟发展一类以碳氢活化为关键起始反应步骤的亚胺不对称芳基加成反应，避免使用芳基金属试剂，为对映选择性合成手性alfa-芳基胺提供一条原子经济性和步骤经济性的新途径。为探索有效的手性催化剂和最佳反应条件，我们针对目标反应提出了较为系统的研究方案，主要侧重于手性配体开发、中心金属筛选、底物设计以及其它反应条件优化。我们拟借助同位素效应、动力学实验、单晶培养、X射线衍射和核磁检测等手段对反应催化机理做系统的研究，以期获取关键反应中间体的结构信息，认识影响反应活性和控制立体选择性的关键因素。最后，希望能发展出有效控制该类反应立体选择性的一般策略，并能在更多的以碳氢活化为关键步骤的催化不对称加成反应中得到成功运用。

Asymmetric catalytic arylation of imines is an efficient way to synthesize synthetically important optically active chiral alfa-aryl amines. In view of the fact that previous reports mainly relied on the use of various aryl metallic compounds such as arylboric acid as arylation reagents, which was less atom-economic, this project aims at developing a new method to realize the asymmetric catalytic arylation of imines with activation of C-H bond as the key step, thus being able to avoid the use of aryl metallic reagents. It will provide a highly atom-economic and step-economic synthetic pathway for the enantioselective synthesis of chiral alfa-aryl amines. To identify an efficient chiral catalyst and optimal reaction conditions, we propose a feasible research plan, mainly focusing on the chiral ligand development, central metal screening, substrate design, as well as other reaction condition optimizations. Moreover, in order to figure out the major factors affecting reactivity and stereoselectivity, we plan to perform a detailed mechanistic studies by means of evaluation of isotope effects, kinetic studies, crystal growing，XRD techniques, NMR detections and so on to collect as much information about the key reaction intermediates as possible. Finally, we wish to develop a general strategy to control the stereoselectivity of such kind of reaction, which may find further applications in other asymmetric catalytic reactions involving activation of inert C-H bond as the key step.