不对称催化碳氢活化反应研究是有机化学的前沿研究方向和研究热点。它旨在采用简单易得的反应原料，通过一步反应即可高效快捷地制备高光学纯的复杂有机化合物。该合成策略原子经济性和步骤经济性高，产生的废弃物少。更为重要的是，它为有机合成提供了全新的断键和成键模式，为合成复杂有机化合物提供了新思路和新路径。因此，该方面的研究具有重要科学意义和实用价值。然而，该研究挑战性极大，目前尚处于起步阶段，研究成果较少。值得注意的是，现有研究表明手性环戊二烯金属络合物CpM（M为钴、铑、铱等过渡金属）是实现不对称碳氢活化反应的有效催化剂。然而，目前报道的手性环戊二烯配体不但种类非常有限，不能满足开发新型不对称碳氢活化反应的需要，而且普遍存在合成复杂，成本高等不足。针对以上研究背景，本项目拟设计新的合成策略，开发一系列新型手性环戊二烯配体，并希望将它们成功应用于不对称催化碳氢活化反应中，取得一些开拓性的成果。

Asymmetric catalytic C-H activation is a frontier research direction and hotspot of organic chemistry. It aims to prepare complex organic compounds with high optical purity by a single step reaction using simple and easily available raw materials. This synthetic strategy is of high atom economy and step economy, and produces less waste. More importantly, it provides new modes of bond breaking and bonding for organic synthesis, and provides new ideas and paths for the synthesis of complex organic compounds. Therefore, the research in this field has important scientific significance and practical value. However, the research is extremely challenging, and is still in its infancy, with few research results. It is noteworthy that existing studies have shown that chiral cyclopentadiene metal complexes CpM (M is cobalt, rhodium, iridium and other transition metals) are effective catalysts for asymmetric C-H activation. However, at present, the reported chiral cyclopentadiene ligands are very limited in variety, which can not meet the need of developing new asymmetric C-H activation reactions. Moreover, the synthesis of chiral cyclopentadiene ligands is complex and the cost is high. In view of the above research background, this project intends to develop a series of new chiral cyclopentadiene ligands by new synthetic strategy, and hopes to successfully apply them to asymmetric catalytic C-H activation reactions and achieve some pioneering results.