骨髓间充质干细胞（BMSCs）来源外泌体具有潜在抗炎活性和免疫调节作用，但其在多发伤合并全身炎症反应综合征（SIRS）中的作用及具体机制仍鲜有报道。我们前期研究发现BMSCs移植可调控大鼠多发伤合并SIRS模型炎症介质释放，抑制NFκB信号分子活化，缓解LPS诱导产生的急性肺损伤。BMSCs分泌产生的外泌体能促进血管内皮细胞迁移，抑制炎性蛋白表达，提示其可能在多发伤合并SIRS中发挥组织保护作用。我们拟进一步研究BMSCs来源外泌体移植在多发伤合并SIRS中的作用及分子机制，深入分析外泌体是否介导下调TLR2,4/NFκB信号通路影响炎性细胞浸润及炎性因子表达，通过改善机体代谢平衡和增强内皮细胞活性发挥减缓“创伤-SIRS-MODS”进程的作用。本研究为BMSCs无创伤修复疗法用于多发伤合并SIRS治疗提供了理论依据，也为发展BMSCs来源外泌体进行有效阻止和干扰治疗该疾病指明了新的方向。

Bone marrow mesenchymal stem cells (BMSCs) have been developed as a potential strategy for controlling inflammation. However, whether BMSCs suppress inflammation in multiple trauma induced systemic inflammatory response syndrome (SIRS) is still not clear. Previous studies have shown that BMSCs have potent anti-inflammation activities and that transfusion of BMSCs can effectively inhibit inflammatory and autoimmune diseases. We found that BMSCs reduced inflammatory injury, inhibited LPS-induced upregulation of TLR2 and TLR4 expression and compromised p65 phosphorylation. In addition, infusion of BMSCs also downregulated the abundance of pro-inflammatory TNFα, IL-6 and IL-1β and upregulated the abundance of anti-inflammatory IL-10 levels in the serum. Furthermore, BMSC-derived exosomes could promote the migration of HUVEC, which is important for angiogenesis and wound repair. In this project, we will investigate the mechanism by which BMSCs suppress the inflammatory reactions. We will also determine how exosomes inhibit the TLR2, 4 mediated NF-κB signal pathway to relieve the progress of “trauma-SIRS -MODS”. The finding will provide the new understanding on the therapeutic value of BMSCs on multiple trauma compound with SIRS, and will provide new strategies for developing exosomes as novel treatment.