手性材料在生物医学、手性识别等领域表现出潜在的应用前景，认识各个层次手性结构的生成动力、调控机制、功能特征等是各个领域科学家面对的挑战课题。针对这一科学问题，结合本人在有机合成和扫描隧道显微技术上的工作积累，本项目拟从微观到宏观系统认识氨基酸手性超分子组装体的调控机制。首先设计并合成一系列手性氨基酸衍生物分子，主要以扫描隧道显微镜(STM)为研究手段，在分子层面上研究二维手性组装体的产生、传递和放大机制。在此基础上采用量子理论化学计算，结合其他技术手段如圆二色谱(CD)、扫描电子显微镜(SEM) 、透射电子显微镜(TEM)和单晶衍射（XRD）等从不同角度揭示三维手性组装体的调控机制与规律，阐明氨基酸手性物质的结构-宏观性质关系，认识调控手性超分子组装体的关键因素；从而探索精准制备手性组装体的方法及其在手性识别中的应用。

Chiral materials show potential applications in biomedical, chiral recognition and other fields. It is a long-standing challenge for scientists in various fields to understand the generation dynamics, regulatory mechanisms and functional characteristics of chiral structures at all levels. In view of this scientific problem, this project intends to understand the regulatory mechanism of amino acid supramolecular chiral assembly from micro to macro, combined with my work accumulation in organic synthesis and scanning tunneling microscopy. Firstly, a series of chiral amino acid derivatives will be designed and synthesized. The mechanism of generation, transfer and amplification of two-dimensional chiral assembly will be investigated at the molecular level by scanning tunneling microscope (STM). On this basis, these techniques are used including quantum theoretical chemical calculation and other technical methods such as circular dichroism (CD), scanning electron microscope (SEM), transmission electron microscopy (TEM) and single crystal diffraction (XRD). The relationship between structure and function will be revealed for amino acid chiral molecules. It will also be explored for the methods of preparing chiral functional assemblies and their applications in chiral recognition.