本项目以若干Cephalotane型三尖杉二萜为研究对象，针对该多环二萜类天然产物中具有合成挑战性的7/5/6/6/-四环结构单元的构建问题，设计了新颖串联“oxa-Michael加成/氧化去芳化/Diels-Alder反应”，结合以semi-pinacol重排为关键的缩环策略，以期为该类多环二萜的集群式仿生合成研究提供新思路、新探索。该研究不仅能够丰富Cephalotane型三尖杉二萜合成研究的内容，同时将为此类二萜化合物可能的生源合成途径做出有益的探索。

In this project, some Cephalotane-type diterpenoids are selected as targets for our synthesis design, wherein how to effectively construct the 7/5/6/6 fused tetracyclic framework constitutes a synthetically challenging issue. Combined with semi-pinacol rearrangement promoted ring contraction strategy, a novel tandem oxa-Michael addition/dearomatization/Diels-Alder reaction is designed as our key step in the bioinspired strategy, providing an opportunity to make some new considerations and explorations to the collective total synthesis of Cephalotane-type diterpenoids. The present studies not only will enrich the synthesis of Cephalotane-type diterpenoids, but also can establish a valuable exploration for proposed biosynthetic pathway.