胃癌是常见的恶性肿瘤，由于早诊率低、缺乏有效的治疗手段，死亡率高。基因组不稳定性是肿瘤发生的早期事件，加强对这些早期事件的研究，有助于提高患者生存期。基于基因组研究，我们识别了中国胃癌患者较为特异的拷贝数扩增基因—ZFP36L2，该基因的拷贝数扩增出现于胃癌早期，且与染色体不稳定性相关。我们的研究结果表明：在早期胃癌中，ZFP36L2的表达水平高于癌旁组织；该基因通过调节细胞周期S期促进细胞增殖；进一步研究发现，ZFP36L2可能通过抑制S期的DNA损伤反应，诱导染色体不稳定。本课题将深入研究ZFP36L2诱导染色体不稳定性的机制；同时，抑制DNA损伤修复的基因可提高化疗敏感性，因此我们也将研究ZFP36L2在预测胃癌患者化疗敏感性中的应用。通过该研究，我们将为胃癌的早诊早治和化疗药物的个体化应用靶标。

In China, the incidence of gastric cancer is very high. Because of the low diagnosis rate in early stage and invalid treatment, the mortality is also high. To study the event occurring in the early stage, such as genomic instability, will increase the survival of patients with gastric cancer. Based on genomic study, we identified ZFP36L2 gene that amplified specific in Chinese gastric cancer patients. The amplification of ZFP36L2 was occurred in early stage of gastric cancer, and was accompanied with chromosome instability. Our results showed that the expression of ZFP36L2 was higher in early stage of gastric cancer tissues compared with adjacent matched normal tissues. ZFP36L2 promoted the growth of gastric cancer cells through regulating S phase. Further, ZFP36L2 could inhibit DNA repair response and then induced chromosome instability. In this study, we will explore the mechanism that ZFP36L2 induces chromosome instability. Because the gene that inhibits DNA repair will enhance the sensitivity of chemotherapy, we will also study the relationship between ZFP36L2 and chemosensitivity. Through this study, we will offer the biomarker and target for gastric cancer individual therapy.