阿魏为新疆特色珍贵药材，在治疗肿瘤、风湿性关节炎、胃痛等方面有独特的优势，根据气味新疆民间分为“臭阿魏”和“香阿魏”，《中国药典》收载新疆阿魏和阜康阿魏均为臭阿魏，但二者已濒临灭绝。臭阿魏植物中还有圆锥茎、大果、托里、臭阿魏等在民间作为药典品种的代用品，但研究基础薄弱，无法合理开发应用。因此，本课题首先调查新疆4种“臭阿魏类”植物的资源分布，探明其蕴藏量；将4种阿魏根提取物分为石油醚、乙酸乙酯、正丁醇、甲醇、水等部位，进行对肿瘤细胞（肝癌、胃癌、结肠癌）增殖抑制、促凋亡的研究；进行对人正常肝细胞、肾细胞增殖抑制和小鼠急性毒性研究，明确阿魏的安全剂量范围。建立HPLC、GC-MS指纹图谱，采用主成分分析和聚类分析对阿魏质量进行综合评价。再采用HPLC法测定阿魏酸、法尼斯淝醇A、C含量。从4种臭阿魏中筛查出蕴藏量丰富、安全有效、有效成分含量高的品种，为新疆阿魏植物的合理利用提供依据。

Ferula is XinJiang precious medicinal material, and has unique advantages in the treatment of tumor, rheumatoid arthritis, stomach pain and other aspects.According to the smell , Ferulic is divided into “Smelly Ferulic ”and “Sweet Ferulic”, Ferula sinkiangensis and Ferula fukanensis are contained in 《Chinese Pharmacopoeia》，but they are on the verge of extinction.Ferula. conocaula、Ferula. lehmannii、Ferula. teterrima、Ferula. Krylovii are used as substitutes of 《Chinese Pharmacopoeia》species in XinJiang folk.But the research foundation was weak, it limited their development and utilization.Therefore, Firstly,We investigate the resource distribution and reserves of four kinds of Ferula plants;Secondly,We divide four kinds of Ferula plants root extracts into petroleum ether fraction, ethyl acetate fraction, n-butanol fraction, methanol fraction，water fraction,Through the proliferation inhibition and apoptosis effects of the tumor cells (colon cancer ,liver cancer, gastric cancer) ,we determine the anti-tumor effects of Ferula plants; Through the proliferation inhibition effects of the normal liver cells, renal cells and acute toxicity study in mice ,we detect the safe dose range of Ferula;Thirdly,We establish HPLC, GC-MS fingerprint, Principal component analysis and cluster analysis are used to evaluate the quality of Ferula.Ferulic acid ,Farnesiferol A, Farnesiferol C are determined by HPLC method.By all of the data,We can screen out Ferula species of rich reserves, safe and effective in use, high effective constituents content from four kinds of Ferula plants.Our study can provide the basis for the rational use of Ferula plants in XinJiang region.