冠心病中西药联用交互作用评价的方法学研究

中西药联用为普遍现象，治疗冠心病联合使用的中西药可多达十几种，药物间的交互作用为研究的焦点问题，目前尚缺少系统分析中西药联用的交互作用，包括增效、减效、减毒、产毒等的机制的研究报道。本研究基于临床科研信息共享系统，以冠心病为切入点，数理统计与数据挖掘相结合，对我单位以往研究收集的13000例临床研究数据信息，采用多因子降维法、复杂网络等挖掘技术，结合置换检验和统计推断，探索建立分析中西药联用交互作用的基本理论和方法，科学评价中西医联合应用的综合效应，阐释中西药联用交互作用的机制，初步建立客观评价中西医结合干预冠心病的临床疗效的方法学平台，这对指导临床规范用药具有十分重要意义。

It is a common phenomenon that combined tradition western medicine and Chinese medicine were widelly used in clinic. There are dozens of ways of combination within western medicine and Chinese medicine for coronary heart disease (CHD). Meanwhile, the interactions become the focus question in research. However, it is seldom to find relevant systematic study about interaction mechanism which include increasing and decreasing effect as well as increasing and decreasing toxicity. Based on Clinical research information sharing system for CHD patients and former information of 13,000 cases, this study used research methods of integrated mathematical statistics method and data mining , multifactor dimensionality reduction and complex network , permutation test and statistical inference, which aims to probe and establish the basic theory and method of interactions between western medicine and Chinese medicine. It is of great significance to evaluate the combined effect of western medicine and Chinese medicine, to explain the interaction mechanism, and to establish a unified methodological platform for clinical effects of coronary heart disease.