因为广泛的内分泌干扰作用和神经毒性，双酚A(BPA)的生产和使用正受到限制，双酚S(BPS)、双酚F(BPF)等双酚类化合物作为替代品应运而生。但是，目前对这类新污染物毒性的认识几乎还是空白。鉴于BPA在甲状腺激素（TH）信号通路上具有甲状腺干扰作用，而BPS、BPF结构与又BPA相似，本项目以TH信号通路研究和甲状腺干扰研究的模式生物----非洲爪蟾为材料，研究BPS和BPF的TH信号干扰作用及其长期暴露的毒理学效应，以评价BPS、BPS替代BPA的安全性。另外，针对"BPA和四溴双酚A（TBBPA）具有TH信号干扰作用，但是否会通过此途径产生神经毒性？"这一科学问题，首先建立一个TH诱导脑发育的非洲模型，为研究由TH信号介导的甲状腺干扰物对脑神经发育的影响提供一个简单快速的方法,然后探讨BPA等双酚类物质由TH信号干扰介导的脑神经发育影响及分子机制，以促进对甲状腺干扰物神经毒性的理解。

The production and use of bisphenol A (BPA) have been restricted due to its endocrine diruption and neurotoxiccity. Thus some new bisphenol chemicals, such as bisphenol S and bisphenol F, emerge as the substitutes for BPA. So far, toxicological data on these new pollutants has been scarce. To evaluate the safety BPS/BPF as the substitues for BPA, we will investigate the disruption of thyroid hormone (TH) signaling pathay by BPS/BPF and toxicological effects of long-term exposure using Xenopus laevis, which is a model for studying TH singnaling pathway and thyroid disruption, considering TH signaling disruption by BPA and similarity of BPS/BPF with BPA.In addition,to explore whether BPA and TBBPA cause neurotoxicity via TH signaling pathway, we will establish a TH-induced brain development model using X.laevis, and provide a new method for exploring brain developmental damage of thyroid disruptors via TH signaling pathway. Using this method, we will study effects of BPA and TBBPA on brain development and related molecular mechanism, which will promote the understanding of neurotoxicity caused by thyroid dsiruptors.