本项目拟设计一种可在纳米尺度上实现MoS2与介孔二氧化硅纳米颗粒（MSNs）复合的新工艺，以将MoS2的光热转换特性与MSNs的高孔容、分散性和生物相容性好等优点整合为一体。首先，基于前驱物在不同介质中的溶解度差异，在溶胶-凝胶法制备的MSNs和MSN-SH孔道内溶剂热合成MoS2。然后，对复合纳米材料进行PEG和RGD修饰，以提高其胶体稳定性和肿瘤靶向能力。MSNs和MSN-SH的孔道结构将赋予复合纳米材料药物控释能力，MoS2则赋予其肿瘤光声造影及光热治疗性能，从而实现导航下的光热治疗/化疗联合治疗。此外，在NIR激光辐射下，MoS2纳米片光热转换产生的热量可促进DOX的释放，有望提高肿瘤的化疗疗效。本项目拟分别从分子、细胞及动物水平分析材料的生物安全性及其肿瘤靶向多模式诊疗效果和机制，相关研究成果将为设计基于MoS2和SiO2的高效肿瘤诊疗平台研究开辟新思路。

This project innovatively proposes a concept for the design and synthesis of composite materials which consist of MoS2 and mesoporous silica nanoparticles (MSNs) at the nanoscale. The design can integrate the excellent photo-thermal conversion capacity of MoS2 and the large pore volume, favorable dispersibility, and admirable biocompatibility of SiO2 into one formulation. Initially, due to the solubility differences of precursors in different solvents, MoS2 will be synthesized by using the in-situ solvo-thermal reaction within the pore structure of the sol-gel synthesized MSNs and MSN-SH. Then, the products will be surface functionalized with PEG and RGD to improve their colloidal stability and tumor targeting ability. In addition, the pore structure of MSNs and MSN-SH will render the composite nanomaterials with controlled drug release ability, while the MoS2 will endow them with excellent tumor photoacoustic imaging and phototherapy performance. Therefore, SiO2/MoS2 and MoS2/SiO2/MoS2 composite nanomaterials can act as efficient therapeutic agents for imaging guided and combined photothermal and chemotherapy of tumor. Furthermore, the photothermal transformation of MoS2 under the NIR laser irradiation is expected to promote the release of DOX and enhance the tumor chemotherapy effect. The biocompatibility, multi-modal tumor therapy capacity of the nano-platform will be evaluated from perspectives of molecules, cells and animals. The launching of this project will provide a novel strategy for the design of MoS2 and SiO2 based nanoplatform for efficient tumor diagnosis and treatment.