昆虫信息素防控农作物害虫符合现代绿色农业发展需要，然而高效活性昆虫信息素因受限于合成难度未能广泛应用。利用昆虫信息素防控农作物虫害是“有害生物综合治理”的重要内容之一。本项目利用甾体皂甙元氧化降解衍生出的含有一个手性分子结构的天然手性试剂为原料，利用计算机辅助药物设计技术，结合活性天然产物结构的特性，通过组合合成和定向多样性导向有机合成，以及官能团转化、碳链延长、手性诱导等手段低成本的集成合成赤拟谷盗聚集信息素、谷斑皮蠹、黄圆蹄盾蚧等带有手性甲基侧链的昆虫信息素及其类似物，测定其生物活性与作用机制、研究其构效关系。在活性测定的基础上，进行三维定量结构与活性关系研究和药效基团分析，对信息素的结构进行简化与优化，以期为开发新型绿色农药提供理论和实验依据。

Pheromone control of crop pests in line with the needs of the development of modern green agriculture, However, highly effective pests pheromones are not widely used due to the difficulty in synthesis. Using pheromone to control pest plays a very important role in "Integrated pest management--IPM". In this item, starting from a abandoned chiral byproduct in steroid industry, based on Compound library design-principles and Computational approaches, through FGI, carbon chain elongation, chiral seduction technology we plan to collectively synthesize the pheromone of Tribolium castaneum, Aonidiella citrina, Diabrotica virgifera and their derivatives. At the same time, we will perform the biological activities test and acticity mechanism of the chemical substances mentioned above. To be guided by 3D-QSAR and pharmacophore analysis, we will simplify and optimize the synthetic pheromone structures focus on confirming the pharmacophore, providing some theoritical and experimental evidences for the developing new generations of green pestcide.