利用现代纳米组装技术制备筛选同时具有高选择性萃取富集能力、良好MALDI电离增强基质效应、便于采样萃取富集器件化和后续质谱检测的复合功能纳米材料，以此为基础构成合适的采样萃取富集器件对复杂环境样品进行采集和处理，并与后续的MALDI-TOF-MS和MALDI-FT-ICR-MS等高分辨质谱以及凝胶电泳-等离子体质谱有机结合，实现高度选择性复合纳米材料与先进的高分辨质谱技术的优势互补，研究建立复杂环境样品的前处理-分析检测一体化分析方法，从而实现污水、大气气相和细粒子等复杂环境样品中微量新型污染物的母体、前体物、异构体、降解代谢产物和暴露标志物的高选择、高灵敏度的快速筛查和分析，为新型污染物的环境行为研究和风险评价提供方法支撑。

Taking advantage of the nanoscale assembly technology, we will synthesize functionalized nanocomposites which not only possesses highly selective extraction ability to targets, excellent desorption/ionization efficiency for targets under the action of laser pulses, but also facilitates subsequent sampling/extraction and mass spectrometry detection. Then the nanocomposites are incorporated into sampling materials or extraction membranes and used to collect atmospheric gas, atmospheric aerosols or pretreat water samples with complex matrix. Emerging pollutants enriched on the nanocomposites are analyzed directly using the subsequent MALDI-TOF-MS, MALDI-FT-ICR-MS or gel electrophoresis-ICP-MS. With the integration of highly selective nanocomposites and advanced high resolution mass spectrometry, trace levels of parent compounds, precursors, isomers, metabolites, and exposure biomarkers in samples with complex matrix such as sewage, atmospheric gas and aerosols, can be identified and analyzed rapidly with high selectivity and sensitivity, which will provide a novel technique to investigate the environmental behaviors and assess the risk of emerging pollutants.