近年来，嗅鞘细胞的抗炎作用开始受到关注，但以巨噬细胞为作用靶点的抗炎机制在OECs移植促进轴突再生及修复脊髓损伤的作用还未明确。因此，本课题拟在骨髓重建嵌合体小鼠的基础上建立脊髓损伤模型，并利用条件性巨噬细胞消融策略消除损伤区骨髓来源的巨噬细胞，然后将携带绿色荧光蛋白的OECs（GFP-OECs）移植入体内，观察小鼠的运动功能和轴突生长情况，以及损伤中心区巨噬细胞活化状态和促炎/抗炎因子表达情况，并且将OECs与巨噬细胞共培养后在细胞水平观察OECs对巨噬细胞吞噬等功能和极化影响，探讨OECs是否通过作用于损伤区骨髓来源的巨噬细胞发挥抗炎作用并促进脊髓损伤功能恢复，为临床应用OECs修复脊髓损伤提供新的理论基础。

The anti-inflammatory effect of olfactory ensheathing cells (OECs) began to concern recently. But whether grafted OECs could promote axonal tisuue regeneration and repair after spinal cord injury by manipulating bone marrow-derived macrophage to regulate inflammation response remain unclear. Therefore, in this study, we will reconstruct bone marrow chimeric mice, establish the model of spinal cord injury and then eliminate bone marrow-derived macrophage within damage area by using the conditional macrophages strategy. After OECs with a green fluorescent protein (GFP-OECs) were transplanted into spinal cord, the movement function of mice and axon growth were observe, as well as inflammatory cytokines and macrophages within the epicenter of injured spinal cord. In addition, OECs are incubated with macrophage in vitro to detect the effect of OECs on the macrophage phagocytosis and polarization and to investigate the relation between anti-inflammatory effect of transplanted OECs via regulating macrophage and the functional recovery of spinal cord injury. The anti-inflammatory effect of OECs against SCI via regulating macrophage polarization may be another important mechanism responsible for functional improvement. It will provide a new theoretical basis for OECs clinical applications to repair spinal cord injury.