本项目模拟人骨无机纳米磷灰石和骨胶原亲疏水微结构，设计纳米磷灰石（HA）与具有亲疏水微结构的聚氨酯复合支架，用于缺损骨组织重建与修复。在合成基于植物蓖麻油和脂肪族二异氰酸酯的软硬嵌段聚氨酯过程中，装载纳米磷灰石仿骨矿物成分，利用聚氨酯自发泡催化特性构建三维多孔复合支架，以期实现良好生物相容性、优异生物活性和有序生物降解性，为不同部位骨缺损提供兼具结构性和功能性的高性能修复支架。其特点是协同有机互穿网络效应和无机纳米效应实现多孔支架力学性能和生物学性能的同步提升，满足骨再生修复的力学和生物活性要求；通过对蓖麻油酯化（羟基化）处理和利用蓖麻油基聚氨酯分子量分布较宽的特点，探索实现支架随着骨组织再生而匹配性地有序降解；研究不同软硬段（亲疏水相）、HA含量和支架微纳结构对力学和降解性能的影响以及在激发细胞生长、介导骨组织再生过程中担负的功能和作用，为开发新型有序降解仿生复合生物材料提供科学依据。

The project imitates the inorganic nano-hydroxyapatite of human bone and the hydrophilic-hydrophobic microstructure of collagen, to design a nano composite scaffold of nano-hydroxyapatite and polyurethane with hydrophilic-hydrophobic microstructure,for regeneration and repair of bone defects. During the block polymerization of castor oil-based polyurethane and aliphatic isophorone diisocyanate,nano hydroxyapatite is addded as bone-like mineral. By using the self-foaming property of polyurethane, porous 3D scaffold can be prepared with good biocompatibility, bioactivity and ordered biodegradability.The scaffold is expected to be high-performance and harmonious on structure and function. Combination of organic interpenetrating network with inorganic nano effect, the scaffold mechanical and biological properties could be improved to match the needs of bone regeneration and repair, meanwhile to realize the ordered scaffold degradation accompanying bone regeneration by transesterification of castor oil with glycerol and ustilizing the wide distribution of molecular weight of castoer oil-based polyurethane.We will investigate the influence of different soft and hard segments (hydrophilic and hydrophobic phase) ，HA content and scaffold micro-nano structure on biomimetic characters and degradability, as well as how it stimulates the cell proliferation and guides the tissue regeneration. The results will be beneficial to provide some scientific evidence for the development of ordered degradable biomimetic composite biomaterials.