动静脉畸形（又称为蔓状血管瘤）严重危害患者的身心健康，多发于口腔颌面部，介入栓塞是其首选的治疗方法。基于组织胶和PVA颗粒的栓塞，因栓塞后异常血管团内皮细胞仍可部分存活，并出现新生血管的形成和血管再通，而导致栓塞治疗后的复发相当普遍。无水酒精由于其脱水和剥蚀作用可使接触的血红蛋白变性并直接破坏血管内皮细胞，阶段性的临床及影像学随访显示，酒精栓塞治疗后动静脉畸形未见明显复发征象。但是，有关无水酒精栓塞治疗后，动静脉畸形内皮细胞及血管平滑肌细胞发展变化的基础研究相当匮乏。本研究拟对无水酒精栓塞治疗后异常血管团内皮细胞及血管平滑肌细胞的形态学及分子生物学变化进行探讨，以揭示其在无水酒精栓塞术后病变的发展及转归中的表现及作用。从而为临床上动静脉畸形的酒精栓塞治疗提供理论依据及技术指导。

Arteriovenous malformations (AVMs), mostly involve the oral and maxillofacial region, are harmful to the sufferred patients, as the physical and psychological issues are corncerned. Embolization is the prefrred therapy for these complicated diseases. However, the recurrence after the embolotherapy which use the glue or(and) PVA as the embolic agents are common in the long-term follow-up.This phenomenon is related to the recanalization and neovascular rectuitment of the residual AVMs, in which part of the vascular endothelial cells are not totally destroyed during the embolization procedure. The periodic clinical and imaging follow-up indicates that the recurrence of the AVMs after the ethanol embolization is not observed by the avoidance of the former mentioned phenomenon, by means of the direct toxic effect of the ethanol which denatures the blood protain and completely destroys the vascular endothelial cells. At present, the basic research of the changes of the vascular endothelial cells and the vascular smooth muscle cells after the ethanol embolization is rare. This study plans to evaluate the development and transformation of the vascular endothelial cells and the vascular smooth muscle cells of the AVMs after the ethanol embolization by the morphological and molecular biology research, which may provide the theoretical basis and technical guidance for the ethanol embolization of AVMs in clinical use.