胃癌包括非贲门胃癌和贲门癌，其死亡率在全世界所有癌症死亡率中排名第二。项目组前期开展了非贲门胃癌的全基因组关联分析（论文发表于《Nature Genetics》杂志），发现5p13.1和3q13.31这两个区域与非贲门胃癌的遗传机制相关，但与贲门癌的发生机制没有显著相关性；同时，还成功验证了8q24、1q22和20p13这三个被报道过的与非贲门胃癌发生机制相关的区域。项目组基于此项研究成果，结合项目组已有的技术优势（部分技术为自主开发，论文发表于《Nature Nanotechnology》杂志），开展非贲门胃癌的后全基因组关联分析（post-GWAS）研究，探索全基因组关联分析发现的易感区域内的致病基因和致病功能位点，并开展大样本验证和功能验证实验，为进一步揭示非贲门胃癌的发病机制奠定基础。

Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. Our research group has carried out a genome-wide association study (GWAS) of non-cardia gastric cancer (published in Nature Genetics), and found two new regions, 5p13.1 and 3q13.31 to be associated with non-cardia gastric cancer. Meanwhile, we also validated the association of three known regions,8q24, 1q22 and 20p13 in this study. Based on those previous findings and the technique advantages of our research group (some technology was developped by us and published in Nature Nanotechnology), we will carry out a post-GWAS research of non-cardia gastric cancer. We will try to find out the causative genes and variants of non-cardia gastric cancer in those susceptibility regions, and validate the findings by replication in large sample sets and functional experiments. Finally, our project will help us understand the etiology of non-cardia gastric cancer much better.