铁死亡是一种铁依赖性的细胞程序性死亡方式，诱导肺癌细胞铁死亡有望成为肺癌治疗的新策略，分子影像手段的结合促进了该策略的可视化研究、实现诊疗一体化。一方面，为了解决基于铁死亡的抗肿瘤策略诱导机制单一的问题，本项目拟将盐霉素的含氟衍生物通过二硫键连接于超顺磁性Fe3O4纳米粒子（SPIONs）表面，通过消耗谷胱甘肽，增加Fe2+/Fe3+含量和引入盐霉素衍生物这三重诱导作用，实现高效地诱导肺癌细胞铁死亡；另一方面，单一的探测手段难以得到相关疾病的全面信息，因此拟发展针对肺癌的双核1H/19F MRI成像新方法，盐霉素的含氟衍生物由于受到SPIONs的顺磁弛豫增强（PRE）效应的影响，可提供肿瘤响应性的19F MRI信号，与1H MRI信号结合，为肺癌的检测提供多视角分子影像信息，从而探索影像指导下的铁死亡治疗新方法，为肺癌的诊疗一体化提供更多可靠的技术。

Ferroptosis has been discovered as a type of programmed cell death driven by iron-dependent lipid peroxidation, which brings light on the development of effective lung cancer therapy. By combining 1H/19F magnetic resonance imaging (MRI), imaging-guided lung cancer therapy is achievable. On one hand, considering the mechanism of ferroptosis, we plan to engineer an iron-based multifunctional nanomaterial. Fluorinated salinomycin derivatives could be loaded on superparamagnetic Fe3O4 nanoparticles (SPIONs) through a disulfide-containing linker, the resulting nanomaterial may induce the ferroptosis of cancer cells, through glutathione depletion, Fe2+/Fe3+ overloading and the introduction of salinomycin derivatives. On the other hand, the fluorinated salinomycin derivative loaded onto the SPIONs is a tumor-responsive 19F MRI probe because of the paramagnetic relaxation enhancement (EPR) effect of SPIONs. The integrated 19F MRI and 1H MRI information will ensure the comprehensiveness and accuracy, which contributing to the imaging-guided cancer specific therapy.