课题基金基金详情
TP-APR阶段缓释电纺纤维支架促进牙周炎相关牙槽骨缺损修复的研究
结题报告
批准号:
82001016
项目类别:
青年科学基金项目
资助金额:
24.0 万元
负责人:
刘瑶
依托单位:
学科分类:
口腔颅颌面组织器官缺损修复与再生
结题年份:
2023
批准年份:
2020
项目状态:
已结题
项目参与者:
刘瑶
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中文摘要
牙周炎相关牙槽骨缺损是口腔常见病理表现,现有牙周治疗对重建严重牙槽骨缺损仍有不足。由于炎症对牙槽骨修复不同阶段产生影响,未有效控制炎症直接促进成骨,难以获得理想骨修复效果。因此早期干预局部炎症,中后期促成骨及矿化的阶段治疗方案可能获得更好的炎症性骨修复效果。在前期研究中申请人构建了“芯壳结构”的阶段缓释电纺纤维,可能对治疗牙周炎相关牙槽骨缺损有积极意义。本项目先构建电纺支架实现阶段缓释策略——初期缓释茶多酚(TP)抗炎,中后期缓释AdipoRon(APR)促成骨并抑制炎性骨吸收;通过体外炎性成骨-破骨细胞模型探索TP-APR阶段缓释电纺支架对炎症,成骨及破骨的多重作用;通过牙周炎动物模型研究TP-APR阶段性缓释电纺支架对牙周炎牙槽骨缺损修复的作用;探讨TP-APR阶段缓释策略对牙周炎牙槽骨缺损的修复及分子机制。本项目将为探索促进牙周炎牙槽骨缺损再生修复的新策略与机制研究提供基础研究依据。
英文摘要
Periodontitis-related alveolar bone defect is a common oral pathological manifestation, of which the reconstruction is still deficient with traditional periodontal therapy. Due to the dual effects of inflammation intervening different stages of bone repair, it is difficult to obtain the ideal bone repair effect by promoting bone formation directly with uncontrolled inflamed environment. Therefore, inhibition of local inflammation at early stage, and promotion of osteogenesis and mineralization at middle/late stage could obtain better bone repair effects with inflamed environment. In the prelimary study, dual staged-released electrospinning scaffold with “core-shell” structure would make a positive difference in therapy of periodontitis-related dental alveolar defects. The staged-released strategy would be obtained through coaxial electrospinning technique, which releases TP fast inhibiting inflammation at early staged, and APR stably promoting osteogenesis and/or inhibiting inflamed bone resorption at middle/late stage. To explore the multiple effects of TP-APR staged-released electrospinning scaffold for inflammation, osteogenesis and osteoclastogenesis, in vitro, osteogenesis-osteolastogenesis cell models with inflamed environment would be used. To study the effect of TP-APR staged-released electrospinning scaffold repairing inflamed alveolar bone defect, in vivo, periodontitis related alveolar bone defect model of mice would be used, while exploring bone repair effectiveness and molecular mechanism. This project will provide basic research evidence for exploring new strategies and mechanisms to promote the alveolar bone regeneration related periodontitis.
期刊论文列表
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科研奖励列表
会议论文列表
专利列表
DOI:10.1080/15476286.2023.2268489
发表时间:2023-01
期刊:RNA BIOLOGY
影响因子:4.1
作者:Liu, Yao;Zhu, Zoe Xiaofang;Zboinski, Elissa K.;Qiu, Wei;Lian, Junxiang;Liu, Shibo;Van Dyke, Thomas E.;Johansson, Hans E.;Tu, Qisheng;Luo, En;Chen, Jake Jinkun
通讯作者:Chen, Jake Jinkun
DOI:10.1002/adhm.202303549
发表时间:2024-05-17
期刊:ADVANCED HEALTHCARE MATERIALS
影响因子:10
作者:He,Ze;Liu,Yao;Luo,En
通讯作者:Luo,En
DOI:10.1016/j.actbio.2021.08.050
发表时间:2021-11-07
期刊:ACTA BIOMATERIALIA
影响因子:9.7
作者:Ji, Huanzhong;Wang, Yiyao;Luo, En
通讯作者:Luo, En
DOI:https://doi.org/10.1016/j.mtbio.2022.100438
发表时间:2022
期刊:Materials Today Bio
影响因子:8.2
作者:Ze He;Shibo Liu;Zhongming Li;Jiazhuang Xu;Yao Liu;En Luo
通讯作者:En Luo
国内基金
海外基金