非卒中房颤伴认知障碍严重影响患者的社会功能。然而，其发生的脑结构基础至今不明。房颤可导致患者执行功能障碍、空间定位能力下降和陈述性记忆缺陷。我们前期的研究构建了与执行功能相关的额叶-纹状体环路，证明了执行功能与该环路的拓扑效率有关。空间定位能力和陈述性记忆可能与海马、颞叶结构有关。我们的预实验发现心功能不全患者执行功能和空间定位能力明显下降；非卒中房颤患者额叶、颞叶的灰白质，以及海马、基底节区的灰质出现明显萎缩。由此，我们提出假说：房颤所致血流动力学改变引起额叶-纹状体环路和海马-皮层环路失连接，可能介导了非卒中房颤认知障碍的发生。本项目拟应用多序列MR，在“天河二号”超级计算机上重建非卒中房颤患者额叶-纹状体环路和海马-皮层环路，运用复杂网络分析方法探讨上述环路连接性，旨在获得上述环路损害介导非卒中房颤患者认知障碍发生的可靠证据，为明确其脑结构基础提供更充分的科学依据。

Cognitive impairment greatly affected social functions in patients with stroke-free atrial fibrillation. However, its neural structural basis is still unknown. Atrial fibrillation could lead to executive dysfunction, spatial disorientation, and declarative memory deficits. In our previous studies, we constructed a frontal-striatal circuit with topological efficiency linked to executive function. Spatial orientation and descriptive memory may be associated with hippocampus and temporal lobe. Our recent research found that the abilities of executive function and spatial orientation decreased significantly in patients with heart failure. We also revealed atrophy in both frontal lobe and temporal lobe, as well as hippocampus and basal ganglia gray matter in patients with stroke-free atrial fibrillation. Thus, we hypothesized that the disconnections of the prefrontal-striatal and the hippocampus-related cortical circuits caused by atrial fibrillation hemodynamic dysfunctions, are linked to the occurrence of cognitive impairment in stroke-free atrial fibrillation. In this project, we will use multiple MR sequences to construct the prefrontal-striatal and the hippocampus-related cortical circuits on the "Tianhe No.2" supercomputer and apply complex network analysis to calculate the connectivity of the above circuits. We aim to obtain reliable evidence for the occurrence of cognitive impairment in stroke-free atrial fibrillation, and provide a new insight into its neural structural basis.