Penicillium expansum是引起苹果、梨、桃、葡萄等大宗水果采后青霉病的主要病原物，不仅造成巨大的经济损失，而且会在果实体内产生棒曲霉素，对消费者的安全造成严重威胁。蓝光是细胞生命活动的重要环境参数，参与病原真菌生长发育、次生代谢等诸多过程，然而关于蓝光对棒曲霉素生物合成的调控机制还未见报道。本研究以P. expansum为对象，研究蓝光与P. expansum生长发育和棒曲霉素积累的关系，观察蓝光处理后P. expansum生长表型及菌体形态和微观结构的变化，揭示蓝光对棒曲霉素积累及相关基因表达的影响，验证蓝光受体与棒曲霉素合成相关因子的互作关系，发现新的受蓝光调控参与棒曲霉素合成的关键因子，并揭示它们与毒素合成的关系，从而在细胞生物学、蛋白质组学、转录组学和分子遗传学水平解析P. expansum的生长发育及棒曲霉素合成的蓝光调控机理。

Penicillium expansum, an important plant fungal pathogen, can infect many fruits, including apple, pear and grape, and cause huge economic losses. Besids, this pathogen is a main producer of the mycotoxin patulin, which is a toxic secondary metabolite of fungal species and is harmful to consumers’ health. Blue light plays important roles in vital activities of fungal cell, and involves in many processes such as growth and development, and secondary metabolism. While the regulation mechanisms of blue light on patulin production have not been documented. In this study, we are using P. expansum to deeply and systemically study the molecular regulation mechanisms of blue light on fungal growth and secondary metabolism. The aims of the study are: 1) to clear the effects of blue light on growth phenotype, hyphal micromorphology and cell structure of P. expansum. 2) to clear the effects of blue light on patulin production and the expression of related genes, and verify the interaction of blue light receptors with the factors involved in patulin biosynthesis. 3) to identify the main factors that participate in patulin production and are regulated by blue light. 4) to illustrate the regulation network of blue light on P. expansum growth and patulin biosynthesis on the level of cell biology, proteomics, transcriptomics and molecular genetics.