甲基苯丙胺成瘾者冲动行为及经颅磁刺激干预研究

甲基苯丙胺成瘾常伴随冲动性用药和冲动行为；其冲动行为是导致戒断后复吸的高危因素，也直接影响了社会安定，而现有治疗手段尚无法对成瘾者冲动性进行针对性康复。本项目将在横断面与纵向(两年期)同时追踪大样本甲基苯丙胺成瘾者戒断后渴求度与冲动性的动态变化，结合脑电记录显示其生理机制，并于不同时间点结合经颅磁刺激干预观察效果。本项目将为经颅磁刺激干预应用于甲基苯丙胺成瘾者戒毒管理，及抑制其冲动行为提供新的措施。

Methamphetamine addiction is often associated with binge drug intake and impulsive behaviors; the impulsivity significantly contributes to relapse, and acts as a risk factor for social security. Current addiction management approaches are limited in reducing impulsivity. The present project aims to track the dynamic changes of craving and impulsive behavior during a two year withdrawal period. The EEG measurement is combined to reveal the underlying neural mechanisms. In addition, the study combines transcranial magnetic stimulation intervention to see potential effects on craving as well as impulsivity. The project will provide rationales for application of transcranial magnetic stimulation intervention in management of methamphetamine addicts, especially in reducing their impulsive behaviors.