本课题运用先进免疫学技术，以人肺成纤维细胞及发病的COPD实验动物为研究对象，以COPD病理特点为研究切入点，以细胞因子为研究介质对COPD进行研究。研究拟以COPD的TGF-β/Smad信号传导通路为实验平台，深入研究COPD发病过程中，在受损的小气道周围细胞外基质的病理改变，明确发病COPD "微型癥瘕"的物质基础，进而确定其发病病机；并通过消癥通络方反证其发病病机。目的是在中医范畴揭示COPD发病机制，探讨中医脏脏气血学说内涵，丰富肺系疾病的学术思想。

This subject to the application of advanced immunological techniques, the incidence of COPD in experimental animals and human lung fibroblasts for the study, COPD pathological features of a research entry point to the cytokine study media for the study of COPD. Study the process of COPD TGF-β/Smad signaling pathway, the experimental platform, in-depth study of COPD incidence, pathological changes in the small airways damage to the surrounding extracellular matrix, a clear onset with COPD "the material basis of the micro Zhengjia and then determine the incidence and pathogenesis; Xiaozheng Tongluo to disprove its incidence and pathogenesis. The purpose is to reveal in Chinese medicine areas COPD pathogenesis explore the blood doctrine of Chinese medicine dirty connotation, the academic thinking of the rich lung diseases.