迄今的研究不能解释为何体外受精-胚胎植入（IVF-ET）后发生输卵管妊娠的概率反而较自然受孕后的更高。课题组前期研究发现，行IVF-ET后输卵管妊娠的母-胎界面上趋化因子受体CCR10及其配体CCL28高表达，其中CCR10的信号来源于胚胎自身。提示这一共存的趋化因子配受体对有可能在输卵管妊娠母-胎界面复杂的生物学现象中起作用。课题验证CCL28/CCR10在行IVF-ET后输卵管妊娠母-胎界面的表达；探索其对滋养细胞增殖和侵袭的促进作用，及对抑制输卵管收缩力和促使输卵管微环境发生利于胚胎植入的生物学作用；探讨激素、细胞因子等对CCL28/CCR10的调控机制。研究将会拓展当前对行IVF-ET后输卵管妊娠发生机制的理解；深化"胚胎因素"和"趋化因子"在输卵管妊娠母-胎界面中重要生物学作用的认识，为预防输卵管妊娠的发生提供新线索。

To date, no research can explain why the probability of tubal pregnancy is higher after undergoing in vitro fertilization - embryo implantation (IVF-ET) than natural conception. Our preliminary study found that chemokine receptor CCR10 and its ligand CCL28 were highly expressed on the maternal-fetal interface of tubal pregnancy after undergoing IVF-ET, especially CCR10 signal derived from the embryonic. The coexistence of the chemokine with the receptor may play complex biological roles on maternal-fetal interface of tubal pregnancy. We will verify the expression of CCL28/CCR10 on the materal- fetal interface of tubal pregnancy after undergoing IVF-ET; explore the role on the proliferation and invasion of trophoblast cells and the role on inhibition of tubal contractility and making the tubal microenvironment conducive to embryo implantation; Investigate the mechanism of regulation of CCL28/CCR10. The study will expand the current understanding of the mechanism of tubal pregnancy after undergoing IVF-ET, deep the understanding of embryonic factors and chemotactic factor playing an important biological role on the maternal interface of tubal pregnancy, provide new clues for prevention the tubal pregnancy occurrence.