创制抗菌、高成骨活性的牙种植体是口腔种植领域一个意义重大但却极具挑战性的问题。申请人基于一种喷砂、二次酸蚀联合减量法表面处理新策略，构建了新的微米/亚微米/纳米多尺度微纳复合结构纯钛表面，体外生物学评价发现这种微纳复合结构钛表面具有表面形貌依赖性的生物学性能，其在窗口期可有效抑制多种细菌的粘附、定植，且具有比经典的微米/亚微米结构钛表面更强的成骨活性。基于此，本研究将探索具有形貌依赖性的多尺度微纳复合结构钛表面选择性抑菌、促进成骨的材料学依据；从活体水平、细胞水平和蛋白、基因水平解析这种形貌依赖性的纯钛种植体表面选择性抑菌、促进成骨作用的生物学机制；并研究窗口期表面抑菌能力对种植体生物学性能和骨整合修复能力的影响和作用，揭示其在牙种植术中的临床意义。

A multiscaled surface topography pattern model integrated with microstructure caused by sandblasting, sub-microstructure offered by a primary acid etching, and nanostructure produced by a secondary acid-etching treatment, was fabricated on Ti-based implant. The surface chemistry of these multiscale hierarchical structured surfaces kept consistent with the micro/submicroscale Ti surface. In pilot biological evaluations, it was found that these hierarchical Ti surfaces possessed topography-dependent antibacterial capacity and stronger osteogenic ability compared with the typical micro/submicrostructured Ti surface. In this study,the materials science basis for selective antibacterial capacity and osteogenic promotion ability of multiscale micro/nanostructured Ti substrates will be explored. The underlying biological mechanism responsible for the topography-driven variation in antibacterial capacity and osteogenic ability will be also studied at levels from animals, cells, to proteins and genes. In the end, the effect of the initial antibacterial capability of the multescale Ti surface on its osteogenic ability and the final osseointegration will be investigated.