离体肝切除技术为常规术式无法切除的肝脏肿瘤患者提供了根治性手术的机会。其中，术中静脉转流是离体肝切除术顺利实施的前提。但现有的静脉转流建立步骤繁琐，耗时长，并且需要进行血液抗凝，这些缺陷限制了离体肝切除术的临床应用。鉴于此，本项目拟使用同轴静电纺丝技术制备一种能够缓释肝素的芯-壳结构复合纳米纤维，并在此基础上研制一种“卜”字形磁吻合静脉转流装置以简化手术步骤、避免血液抗凝，通过动物实验评价其便捷程度及免抗凝效果，探索门腔转流安全时限，观察其对离体肝切除模型的生存影响，并探讨新型转流装置的适应症及改善预后的相关机制，为进一步临床应用奠定实验基础。

Ex-vivo liver resection provides an opportunity for radical surgery for patients with liver tumors that cannot be resected by conventional surgery. Intraoperative venous bypass is the premise of ex-vivo liver resection. However, the establishment of venous bypass is tedious and time-consuming, and systemic blood anticoagulation is needed. These defects limit the clinical application of ex-vivo liver resection. In view of this, this project intends to use coaxial electrospinning technology to prepare a core-shell structure composite nanofiber with slow release of heparin, and on this basis to develop a "y" magnetic anastomosis venous bypass device to simplify the operation procedure and avoid systemic anticoagulation. Its convenience and anticoagulant-free effect were evaluated by animal experiments, and the safe time limit of portacaval bypass was also explored. The indications of the new bypass device and the mechanism of improving prognosis were discussed in order to lay an experimental foundation for further clinical application.The indications of the new bypass device and the mechanism of improving prognosis were discussed in order to lay an experimental foundation for further clinical application.