瘟疫灾害是传染病大规模流行所致的疾病灾害，是威胁人类健康的顶级自然灾害之一。在“健康中国”建设及全球气候变化背景下，选择处于“明清小冰期”前段的明代为研究时段，建立明代地图数据库、瘟疫灾害数据库和气候变化数据库，从地理学、历史学、流行病学、气候学等多学科视角出发，综合运用文献分析、空间分析、小波分析、数理统计等方法，研究明代疫灾的时间变化特征、空间分布规律，以及明代疫灾变化与气候变化的时空对应关系。在理论上，有利于拓展历史医学地理学的研究内容和方法，推动历史医学地理学的发展；在实践上，有利于增强对气候变化健康效应的认识和应对，为当前政府部门制定传染病防治规划、完善传染病防治体系、防控重大突发性公共卫生事件、维护社会稳定提供历史经验和科学依据。

The epidemic disaster is a kind disaster caused by the pandemic of infectious diseases, and it’s one of the climax natural disasters which threat the human health. On the background of the "Healthy China" construction and the global climate change, the Ming Dynasty is selected as the study period which is in the early stage of the "Little Ice Age of the Ming and Qing Dynasties", and establish the Ming Dynasty historical map database, epidemic disasters database and climate change database, from the multidisciplinary view of geography, history, epidemiology and climatology, using the methods of document analysis, spatial analysis, wavelet analysis and mathematical statistics, to analyze the scientific questions including the temporal variation characteristic, the space distribution pattern，and the spatial and temporal correspondence between the epidemic change and climate change in the Ming Dynasty. In theory, this study can improve the development of historical medical geography by expanding the research contents and methods. In practice, this study can help increase awareness and response to the health effects of climate change, and also can provide historical experience and scientific base for the government to make infectious disease prevention plan, improve the infectious disease prevention system, prevent and control the emergent events of public health, and maintain the social stabilization.