2014年联合国艾滋病规划署提出加强对艾滋病高风险感染人群的关注是消灭艾滋病的关键。HIV感染者/AIDS患者存在较多生理、心理症状和行为问题，影响其抗病毒治疗的依从性和患者的生活质量。前期研究发现，我国在该领域的实践尚存在按经验决策的现象，且照护活动较为分散、专业性和整合性不足，影响了患者治疗的依从性和有效性。本研究拟在充分调研我国艾滋病预防和控制发展趋势、政策背景、实践现况的基础上，聚焦艾滋病症状管理和照护活动中的关键问题，进行该领域证据的系统综合和提炼，以“知识转化理论”为框架，以循证医学方法为指导，构建HIV/AIDS患者症状管理和整合式照护领域知识转化和循证决策模型，通过实证研究，对模型进行验证、评价和优化，探索其在改善HIV/AIDS患者症状发生情况、治疗依从性、促进身心健康、提高其生活质量上的有效性、可行性和适宜性，并探索出HIV/AIDS患者症状管理和整合式照护的有效机制。

In 2014, UNAIDS stressed that focusing on the high risk population is the key to eliminate AIDS. Faced with problems from physical, psychological symptom and behavioral aspects, PLWHAs’ compliance with anti-virus treatment and quality of life are greatly influenced. Previous studies found that, there still remained empirical decision-making in this area, leading to scattered caring activities without enough professionalism and integrity. Consequently, the compliance and effectiveness of PLWHAs’ treatment has been greatly impaired. This study will firstly, investigating the development, policy background and current practice of China’s prevention and control on HIV/AIDS. Then, systematic reviews and evidence synthesis will be performed, centering on key issues on symptom management and caring activities. Guided by “knowledge translation” and “evidence-based medicine”, a model of knowledge translation and evidence informed decision-making on symptom management and integrated care will be established. This model will be validated and optimized by an empirical study. Thus, the effectiveness, feasibilities and appropriateness of the model will be explored, in PLWHAs’ symptom and compliance improvement, physical and psychosocial health, and upgrading quality of life. An effective mechanism of PLWHAs’ symptom management and integrated care, will become driving force and technological support in scientific and evidence-based relevant policies making.