地震幸存儿童精神健康水平与其脑区激活关联研究

经历地震等重大灾难可导致幸存儿童心理问题，甚至会有自杀倾向，这对于我国未来经济发展和社会安定都有着至关重要的影响。针对当前对地震幸存儿童的精神健康水平的研究较少关注他们的长期精神健康水平与其大脑关联、较少关注无明显相关症状的幸存儿童的精神健康、较少关注地震幸存儿童与正常儿童脑功能的比较等问题，本项目以2013年雅安地震幸存儿童为研究对象，采用静息态功能磁共振成像（fMRI）技术，以脑区激活与精神健康水平关联为核心，以基于静息态fMRI技术的地震幸存儿童脑功能连接模型为基础，系统研究幸存儿童脑功能连接与其精神健康水平关联机制、幸存儿童差异显著脑功能连接强度与其精神健康水平相关机理等关键科学问题，为地震幸存儿童精神健康问题的早期诊断和治疗提供客观有效的理论和技术支撑，最终达到全面提高我国儿童精神健康水平的目的。

Experiencing a disaster such as an earthquake can lead to psychological problems and even suicidal tendencies for surviving children, which will have a crucial impact on China's future economic development and social stability. In view of current research on mental health of children survived in earthquake, they pay little attention to the relation between long-term mental health and their brain activation, to the mental health problems of children who are not significantly related to certain symptoms, and to the comparisons of brain function between child earthquake survivors and normal children. This project is based on the 2013 Ya'an children earthquake survivor as the main research object.We employ the resting state functional magnetic resonance imaging (fMRI) technique, with the association between brain activation and mental health as the core, and with the children survivors’ brain functional connectivity model based on the resting state fMRI technology as the basis. We systematically study the key scientific problems, including the association mechanism between children survivors’ brain functional connectivity and their mental health, between the significant differences in the strength of their brain functional connectivity and their mental health, to provide theoretical and technical support for early and effective diagnosis and treatment for the mental health problems in children earthquake survivors, and ultimately to improve children's mental health level for the purpose of our country.