基于独特“氟效应”的有机氟化学研究

尽管氟元素在自然界中大多以无机氟化物的形态存在，但是越来越多的经人工合成的有机含氟物质（含有碳-氟键的物质）具有非常优秀的物理、化学、生物特性，在材料科学和生命科学等领域发挥着不可替代的关键作用。目前，有机含氟物质的绿色高效合成已经成为整个化学领域的热点研究领域。本项目将从研究和理解含氟分子独特的“氟效应”入手，深入研究氟化反应、氟烷基化、氟烯基化反应等几类反应之间的相关性，特别注重利用成本相对低廉的可用于氟化和氟烷基化反应的原料，发展出若干具有我们自主知识产权、实现在全球商品化销售、在国际上具有一定影响力的氟化学试剂。本项目还将系统研究基于这些试剂的新型氟化学合成反应，并把这些新试剂和新反应应用于相关材料分子的合成中。通过该重点项目的研究，为氟化学学科发展和我国氟化工产业的发展提供科学技术支撑。

Although fluorine usually exists in form of inorganic fluorides in our Nature, more and more man-made organofluorine substances (containing C-F bond) demonstrate excellent physical, chemical, and biological properties, which play crucial roles in life science and material science-related fields. Currently, the highly efficient and green synthesis of organofluorine substances is one of the hot topics in chemical science. This project aims to investigate the relationships between fluorination, fluoroalkylation, fluoroolefination via probing the unique fluorine effects. In particular, this project focuses on the use of low-cost materials and the development of novel, globally commercializable, high-impact fluorochemical reagents and related reactions, which can be used in the synthesis of fluorinated functional materials. This project is expected to provide scientific and technological support for the advance of fluorine chemistry as well as for the Chinese fluorochemical industry.