近年来，大量研究表明新生血管是动脉粥样硬化疾病普遍存在的特征, 新生血管在不稳定性斑块及斑块的易损部位更为明显,它是动脉粥样硬化发生发展的重要危险因素,与临床心脑血管事件的发生显著相关。有报道，斑块内的新生血管绝大部分来源于血管的外膜滋养血管，因此，应用影像学技术评估血管外膜滋养血管及斑块内新生血管, 在早期发现动脉粥样硬化病变部位及辨识斑块稳定性,预测心脑血管意外的发生及早期预防，评价临床治疗疗效等方面具重要作用。.本课题通过构建家兔动脉粥样硬化模型，利用超声造影方法，观察兔颈总动脉外膜滋养血管与斑块内新生血管的情况，研究血流灌注方式，探索两者之间的关系，同时采用病理及免疫组织化学方法，证实两者在动脉粥样硬化中的作用和相互关系，为揭示动脉粥样硬化病因学及临床早期诊断动脉粥样硬化提供理论依据。

In recent years, a large number of studies have shown that neovascularization is a common character of atherosclerotic disease. Neovascularization was more obvious in vulnerable parts of the unstable plaque and frangible plaques. It was significantly associated with cardiovascular and cerebrovascular events in clinic and was considered to be an important risk factor for atherosclerosis development. It was reported that, most of the neovascularization within the plaque was nourished by the adventitial vascular. So, early evaluation of the adventitial vascular and the neovascular in the plague by using radiologic techniques was important for the prediction and prevention of cardiovascular and cerebrovascular accidents. .This study was design to reveal the etiology of atherosclerosis to provide theoretical basis of the early diagnosis of atherosclerosis. In this study, we established a rabbit atherosclerotic model. The adventitial vascular and the neovascular in the plague were assessed by contrast ultrasound. Association between the blood perfusion and the vascular was explored by pathological and immunohistochemical methods.