Behcet病是我国常见的高致盲性眼病之一，该病的发病机制目前尚不明确。最近研究发现肠道微生物异常可能与一些自身免疫性疾病的发生存在一定相关性。我们既往研究中发现，白塞氏病患者体内肠道微生物组成有显著改变，这提示肠道微生物构成的异常可能与该病的发生有关。最近的研究还发现肠道微生物可以通过影响肠道代谢产物——胆汁酸从而调节自身免疫应答。本研究以此为切入点，以葡萄膜炎动物模型为研究对象，探讨胆汁酸对动物葡萄膜炎发生、严重程度及转归的影响及对局部和全身免疫反应的影响；探讨动物葡萄膜炎模型中肠道菌群异常与胆汁酸代谢异常的相关性；探讨胆汁酸对DC诱导CD4+T细胞分化及功能的作用及分子机制，确定其参与疾病发生的具体机制。通过上述研究，将有望获得肠道微生物特异性代谢产物对自身免疫性葡萄膜炎发生的影响及其机制，以进一步阐明葡萄膜炎的发病机理，为该病的预防和治疗研究提供新方向。

Behcet disease (BD) is one of the most common disease which will cause blindness in China, however, the exact mechanism is still not fully understood. Recent studies have indicated that gut microbiota was involved in the pathogenesis of some autoimmune diseases. In our previous studies, a significant segregation of gut microbiota was found in BD patients, suggesting that gut microbiota is involved in the occurrence of BD. Recent studies have also suggested that gut microbiota regulated the autoimmune response by gut metabolites——bile acids. Therefore, the present study will investigate the effect of gut metabolites on the experimental autoimmune uveitis (EAU) model. Firstly, we will study the effect of bile acids on the development of EAU and the immune response in vivo. Secondly, we will study the correlation of gut microbiota with bile acids in EAU mice. Finally, we will study the effect of bile acids on the induction of CD4+ T cells by dendritic cells as well as the underlying mechanism. Collectively, it is expected to figure out the effect and mechanism of gut microbiota specific metabolites on the development of EAU; Meanwhile, these studies will add a new insight into the pathogenesis of EAU and provide new strategies for the prevention and treatment of uveitis.